Problematic substance use complicates treatment for youth and families who have been impacted by trafficking and commercial sexual exploitation (T/CSE). Panelists draw from their experiences leading multiple national anti-trafficking programs to explore common challenges when working with exploited who struggle with problematic substance use. The discussion include essential guidance for providers working with impacted youth, including treatment guidelines from the National Center on Child Trafficking that focus on the intersection of substance use and T/CSE.