Children’s Advocacy Centers (CACs) are youth- and family-centered settings staffed by professionals with expertise in child trauma and sexual abuse. CACs facilitate multi-disciplinary team collaboration and communication and offer an array of services in one collocated setting. Many strengths of CACs match key aspects of effective trafficking response, including the importance of trauma-informed services, multi-disciplinary/multi-sector response, and robust case management and advocacy. CACs often play a central role in trafficking response, especially assessment, service delivery, and multidisciplinary team coordination. In fact, many CAC professionals have been thought leaders in their communities in response to trafficking and commercial sexual exploitation of children, establishing innovative programs that leverage child trauma, sexual abuse, and systems expertise and existing robust multidisciplinary collaborative partnerships to enhance services to youth and their families. This workshop will provide an overview of Children’s Advocacy Centers, describe essential components (“Standards”) and diverse features of CACs, especially those that feature most prominently in trafficking response as well as robust discussion of challenges and obstacles faced by CACs, their partners in trafficking response, and experiences of survivors and their families with CACs. We will then review exciting specialized trafficking programs and services developed and coordinated through individual CACs and state chapter organizations - Chicago CAC, Suffolk County CAC (Boston) and MACA, Georgia CACGA CSEC Response Team - that build on existing knowledge and resources of the CAC while also flexibly expanding partnerships and service delivery to better meet the needs of trafficked youth.